Hodgkin lymphoma: What is it?

One type of lymphoma is Hodgkin lymphoma. This is a cancer that affects the immune system. Lymphoma refers to cancer that starts with cells of the immune system known as white blood cells or lymphocytes. About 10% of cases of lymphoma are Hodgkin lymphoma. The cause of Hodgkin lymphoma is unknown, although some factors that put individuals at risk include.

It may be hard to detect Hodgkin lymphoma as it usually does not have symptoms in its initial stages. Symptoms of Hodgkin lymphoma include fever, drowsiness, night sweats, swollen lymph nodes, and unexplained weight loss. Fortunately, there are treatments for Hodgkin lymphoma. The severity of the disease and your overall health will determine the course of treatment, which encompasses a variety of options. If you experience symptoms of Hodgkin lymphoma, you should see your doctor.

Hodgkin lymphoma types

Classic Hodgkin lymphoma is the most common type of Hodgkin lymphoma, but there are others too. About 90 percent of all cases of Hodgkin lymphoma are classified as classic.

Classic Hodgkin lymphomas According to the American Cancer Society, there are four categories of classic Hodgkin lymphomas. What is Hodgkin lymphoma.

  • Sclerosis of the nodules About 70% of cases of Hodgkin lymphoma are of this kind, which is the most common. Although it can occur at any age, it mostly affects teenagers and young adults.
  • Cellularity mixed The second most common type of lymphoma, Hodgkin lymphoma, is most commonly diagnosed in HIV-infected patients.
  • Lymphocyte-rich Hodgkin lymphoma: This is one of the rarest forms of cancers. It usually involves the upper body.
  • Low lymphocytes Hodgkin lymphoma: The disease is usually caused by this unusual and aggressive type of disease in people who have HIV.

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), which constitutes about 5% of all cases, is another type of Hodgkin lymphoma besides the classical type. This type of lymphoma usually progresses slowly and requires a specific approach to treatment.

The American Cancer Society. Hodgkin Lymphoma: What Is It.

Symptoms of Hodgkin lymphoma

In the early stages of Hodgkin lymphoma, it is common to have no symptoms. Early identification and therapy may become difficult as a result. Thankfully, one of the most treatable malignancies is Hodgkin lymphoma. The prognosis may improve if the symptoms are identified as soon as feasible.

An enlarged lymph node is the most common first sign of Hodgkin lymphoma. A painless lump under the skin is how an enlarged lymph node feels. You may notice more lumps as the cancer progresses. Typically harmless, swollen lymph nodes can become painful after alcohol consumption.

It is helpful to remember that swollen lymph nodes are a symptom of many diseases, such as infections. When you find a new lump under your skin, you feel upset, although the cause is mainly harmless. Whenever you have any Hodgkin lymphoma symptoms, you should always consult your doctor.

The American Cancer Society lists the following other common signs of Hodgkin lymphoma. cancer from lymphoma.

  • Night sweats: Whether or not you feel hot, you wake up drenched.
  • Loss of weight: Losing ten percent of your body weight in six months without trying or planning
  • Weariness: Feeling tired or listless even after adequate rest.

Depending on which body parts are affected, other Hodgkin lymphoma symptoms can vary. You can experience chest pain, shortness of breath, and coughing if the cancer cells were formed in your chest. Skin itching, loss of appetite, and abdominal pain are some more possible symptoms.

The American Cancer Society. Symptoms and signs of Hodgkin lymphoma.

Reasons

When cancerous cells proliferate and disperse within a lymphatic region, Hodgkin lymphoma develops. This usually presents in the lymph nodes although it can also occur at the spleen or within the bone marrow. Since there are identified risk factors that can increase your chances to develop Hodgkin lymphoma, the specific cause of this disease is still unknown.

Researchers believe that Epstein-Barr virus (EBV) is linked to Hodgkin lymphoma. The EBV virus causes mononucleosis or mono. EBV has also been known to mutate DNA and increase the possibility of getting lymphoma. Cancerous cells may find their way into white blood cells called B lymphocytes. Research is being conducted on the possible connection.

Risk Factors

Any element that influences your chances of contracting a certain illness, such as Hodgkin lymphoma, is considered a risk factor. Having a risk factor does not guarantee that you will get the illness. It only means that you are more at danger than the other person who has no risk factors.

Many Hodgkin lymphoma risk factors are irreversible. Some of these risk factors include the American Cancer Society. The risk factors for Hodgkin lymphoma.

  • The Epstein-Barr virus (EBV) might cause genetic alterations that tend to increase the risk for lymphoma.
  • Age: Younger persons in their twenties and older adults over 55 are most likely to develop Hodgkin lymphoma.
  • Sex: Men are more likely than women to get Hodgkin lymphoma.
  • Family history: If your sibling has Hodgkin lymphoma, you are at an increased risk of getting it yourself. For an identical twin, the risk is extremely high.
  • Immune system weakness: Hodgkin lymphoma has been reported to be a more common disease in the weak immune system, for instance, caused by HIV or taking some drugs.

How is a diagnosis of Hodgkin’s lymphoma made?

Your doctor will prescribe specific tests depending on your symptoms, medical history, and general health. There are various tests that can be done to diagnose Hodgkin lymphoma. Most patients with Hodgkin lymphoma go to see their doctor when they begin to experience some symptoms or feel generally unwell.

Your provider will begin with a detailed physical and history. This would include a physical check to look for signs of enlargement in the liver, spleen, or lymph nodes. He will also question several things related to your history and your symptoms. They may recommend that you should consult an oncologist-a doctor specializing in the diagnosis and treatment of cancer.

The first-and-sometimes-the-only sign of Hodgkin lymphoma is often an enlarged lymph node. Prior to employing more invasive diagnostic techniques, your doctor may instruct taking antibiotics for a time since swollen lymph nodes are also associated with a number of milder illnesses. Other tests will likely be recommended if the antibiotics fail to alleviate your swelling.

For any diagnosed Hodgkin lymphoma, a lymph node biopsy will follow. Depending on your case history and examination report, your healthcare practitioner will recommend what type of biopsy would best be suited for you. Some kinds of tissue biopsies are.

  • Excisional biopsy: Whole lymph node removal and examination
  • A part of the lymph node is removed and examined in an incisional biopsy.
  • A small amount of fluid is drawn out using a thin, hollow needle. This procedure is called a fine needle aspiration biopsy.
  • Core needle biopsy: Removing a bigger portion of tissue with a bigger needle.

After the diagnosis of lymphoma, your doctor might recommend a bone marrow aspiration to check for cancerous cells in the bone marrow.

Blood tests are often used to diagnose malignancy. Blood tests to expect are.

  • It detects a high white blood cell count by a complete blood count, or CBC.
  • ESR, or erythrocyte sedimentation rate, assesses the level of inflammation in the body
  • Tests for kidney and liver function: Determine if the kidney or liver is enlarged.

Hodgkin lymphoma can also be diagnosed through other tests.

The American Cancer Society. Diagnosis of Hodgkin Lymphoma.

  • Some types of proteins on cells that may predispose someone to Hodgkin lymphoma are identified through immunohistochemistry.
  • Chest X-ray: Examines the chest’s enlarged lymph nodes
  • CT, or computed tomography: scans the neck, chest, abdomen, or pelvis for signs of lymphoma.
  • MRI is only rarely used, but sometimes cancer needs to be imaged in the brain or spinal cord.
  • PET scan (positron emission tomography): finds cancerous cells with imaging.
  • Do the bone scan only if you are suffering bone pain, since it will help check if the cancerous cells have migrated to the bone.

Therapy

Remission is treatable for Hodgkin lymphoma. “Remission” refers to a period when a disease’s symptoms disappear. Treatment for early-stage Hodgkin lymphoma aims for remission. Treatment in the later stages aims to alleviate symptoms to improve your quality of life.

Treatment of Hodgkin lymphoma will depend on several variables that include your disease subtype, stage, symptoms, and general health. Based on the American Cancer Society, the following are among the most common therapies of Hodgkin lymphoma.

  • Chemotherapy: Anti-cancer medications administered orally or intravenously (IV).
  • Radiation treatment: Treatment for decreasing size of tumour or the bigger lymph nodes.
  • Immunotherapy: Medication that enhances the body’s immunity against cancer; it can be administered orally in the form of tablets or pills, or intravenous in the form of infusions. Immunomodulating medicines, immune checkpoint inhibitors, monoclonal antibodies are a few examples.
  • A stem cell transplant is a procedure that helps in reconstituting the bone marrow. It is usually kept for those in whom radiation and chemotherapy have been unable to improve your condition.

Avoidance

It is often impossible to prevent Hodgkin lymphoma. Many of the risk factors for this type of cancer are irreversible. Variables such as your age and family history are outside of your control. It’s also important to remember that most patients with Hodgkin lymphoma do not have any of the risk factors.

Consult your healthcare provider to discuss your risk level and whether there are ways to reduce your risk of developing Hodgkin lymphoma if you have risk factors for the disease

Having Hodgkin’s disease

Living with Hodgkin lymphoma is hard, and it’s not unusual for the illness to disrupt every area of your life. Receiving a diagnosis of Hodgkin lymphoma is a life-changing experience.

Most days, people with Hodgkin lymphoma are filled with a myriad of emotions. Some feel angry, hopeless, anxious, overwhelmed, and lonely.

National Cancer Institute. Cancer and emotions.

Consider reaching out to a mental health professional. You may also find it helpful to make a list of the things that bring you happiness and start planning those activities into your time. Learning the stress-reduction techniques including diaphragmatic breathing are helpful, too.

Don’t go through Hodgkin lymphoma treatment alone; it is a daunting process. As much as you can, rely on your loved ones. Think about requesting assistance with babysitting, transportation to doctor’s visits, food preparation, and other tasks.

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